Product Validation

Validation of the product on a portable PCR platform is in progress in with a compatible sample preparation method for use in locations with little infrastructure (“point of care”).

Malária

Malaria is a disease that affects millions of people in more than 90 countries around the world. It is estimated that 300 to 500 million new cases occur every year, with almost 40% of the world population living in risk areas. In Brazil, data from 2003 point out to just over 400,000 cases per year (Malaria Diagnosis Manual of the Ministry of Health, 2009). It is known that two of the main factors for reducing the mortality rate are early diagnosis followed by effective therapy. This project focus on diagnosis improvement.


The goal is to develop a test to aid in the diagnosis of malaria by detecting the DNA of its causing agent. Thus, priority was given to the detection of parasites circulating in Brazil: Plasmodium falciparum and Plasmodium vivax. However, results were also obtained for the detection of P. malariae and P. ovale.


Initiated in 2011 as a collaboration between IBMP, Fiocruz, CDC (USA) and National Institute of Health (Mozambique), in 2015 the project got new partners, including the Center for Tropical Medicine Research (CEPEM-Rondônia) and a new team. In 2018, the development of reaction for use in bench equipment was completed. Some of the reaction development data were recently accepted for publication in the Journal of Molecular Diagnostics.

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